Saccharomyces Boulardii

80 capsules |up to 80 days' supply

4.6/5 (71 reviews) Read verified product reviews
4.6/5 (71 reviews) Read verified product reviews
Dr Sasivimol Ahmed PhD, PG Dip (Personalised Nutrition), BSc (Food Science)
Recommended often, Saccharomyces boulardii is a friendly yeast and has been used safely around the world for over 50 years.
Dr Sasivimol Ahmed
Dr Sasivimol Ahmed PhD, PG Dip (Personalised Nutrition), BSc (Food Science)

Who is it for?

With 5 billion live cultures per capsule, this is for anyone looking to purchase a pure Saccharomyces boulardii supplement an extensively researched, unique friendly yeast proven to reach the gut alive.

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FREE UK delivery on orders over £40.

UK express - Monday to Friday delivery.

See our Delivery & Returns for more information.

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  • Vegan


  • No dairy

    No dairy

  • Gluten free

    Gluten free

  • Soy free

    Soy free

  • No added sugar

    No added sugar

  • Artificial colour free

    Artificial colour free

Key benefits

A pure Saccharomyces boulardii supplement

  • Pure Saccharomyces boulardii supplement Optibac Saccharomyces boulardii contains 5 billion live cultures of pure S. boulardii, guaranteed until end of expiry
  • Digestive supplement Complements the natural gut bacteria
  • Internationally acclaimed Used around the world for 50 years, Saccharomyces boulardii live cultures are extremely well-researched 
  • Scientifically proven Shown in clinical trials to survive stomach acidity and reach the gut alive
  • Travel friendly With no need for refrigeration, even in hot, humid environments, you can take this easy-to-swallow supplement with you wherever you go
  • Natural and vegan Vegan, gluten free for those with coeliac disease, and made with absolutely no artificial flavourings or colourings
  • Suitable for daily use Can be taken intensively or on a long-term basis
  • Saccharomyces boulardii UK Optibac was the first brand to introduce S. boulardii to the UK 
  • Highly recommended From the UK’s most trusted & recommended brand of friendly bacteria supplements.

Optibac Probiotics strains

  • Saccharomyces boulardii
See full ingredients list

Complements gut bacteria


General digestive

Customer reviews

4.6/5 (71 reviews)
  • Absolutely love this product. Use it regularly with many of my clients. Also like to combine with 'for when on antibiotics'. Highly recommend many of Optibac products.

    Nicola Warran- 29th June 2022

  • I have tried other probiotics but I have found Optibac S. Boulardii suits me very well and I can tell the effect even on the improvement in my skin. Customer service couldn’t have been more courteous and helpful when I emailed about a question I had.

    Mrs Judy Morris- 9th November 2021

  • I am a big fan of Optibac probiotics. They are consistently great quality & are always delivered well packaged & quickly. Highly recommended

    Nina- 2nd September 2021

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Help & advice

Speak to our team of experts (nutritionists, microbiologists and nutritional therapists) any time for free advice, with absolutely no obligation to buy.

Camilla Gray
Camilla Gray DipCNM Nutritional Therapist

Why choose us?

We are the UK's most trusted & recommended brand of friendly bacteria supplements.

† As determined in an independent survey of 1000 British women.

  • How to use

  • Ingredients

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  • Delivery & returns

  • How to use

    Recommended use

    Natural food supplement suitable for adults and children (from 1 year onwards) with the following recommendations:

    • Take 1 capsule daily. May be increased up to 6 capsules daily as desired (depending on severity of symptoms) or as professionally directed.
    • For young children the use should be lowered. 1 capsule daily, may be increased up to 3 capsules daily.
    • If taking anti-fungals, take separately (at least 2 hours apart).
    • For those unable to swallow capsules, open and mix contents with a cool drink/food..

    Storage instructions

    • For best results, do not remove desiccant sachet from the glass jar and close lid firmly after each use.
    • Store in a cool, dry place below 25°C and out of direct sunlight.


    Live cultures are not recommended for those with serious medical conditions e.g. those who are severely immunosuppressed, have pancreatitis, are in the ICU, have melaena, have a central venous catheter, short bowel syndrome, or patients with open wounds following major surgery; unless under a doctor's care. Keep out of reach of children.

    Gut health supplements are not intended to prevent, treat or diagnose any medical conditions. If taking probiotic supplements for gut health, note that these should not be used as a substitute for a varied and balanced diet and a healthy lifestyle. If you are taking any medications or have a serious medical condition, consult a doctor before use. Optibac supplements will not cause dependency and may be used on an ongoing basis.

    Pregnant or breastfeeding women should consult their doctor before taking Saccharomyces boulardii.

  • Ingredients


    Live cultures: Saccharomyces boulardii (275mg); vegetarian capsule: hydroxypropyl methylcellulose

    Each capsule guarantees 5 billion live cultures.


    • Vegan
    • Vegetarian
    • No dairy
    • Gluten free
    • Soy free
    • No added sugars
    • Free from artificial flavourings, colourings and preservatives
    • No chemicals or parabens
    • GMO free
    Format Capsule
    No. Live Cultures 5 billion
    Recommended Use 1 capsule daily
    Age Range Adult
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  • Delivery & returns

    UK Delivery

    Free UK Delivery over £40 
    Free standard UK delivery is automatically applied at the checkout when you spend £40.

    Standard 2nd class: £2.50
    Allow 4-10 working days (Monday - Friday) for delivery

    1st class: £3.95
    Allow 1-3 working days (Monday - Friday) for delivery

    Express Next Day (Tracked): £6.95 (Dispatching Friday 30th December)
    Order before 2pm for 1-2 working day delivery to most of the UK*. Orders placed on Friday will be delivered on Monday (next working day). Requires signature.
    Please be aware of Christmas Bank holidays.

    Shipments will be dispatched via DHL or FedEx, the service will be selected depending on the delivery location.

    *Express delivery may exclude the Channel Islands, Herm Island, Isle of Man, Isle of Wight, Northern Irish postcodes BT18 & upwards, Sark, Scottish borders and offshore and a small number of remote mainland destinations as determined by our delivery courier. 

    Good to know

    • We'll send you an email to confirm once your parcel has been dispatched.
    • For delivery queries, please call us on +44 (0)1264 339 770 or email
    • Orders placed before 2pm are typically dispatched on the same working day.
    • Delivery within the UK and Northern Ireland has a fixed price, regardless of the size and weight of your order. 
    • Delivery times are estimates and not guaranteed unless otherwise stated.

    International Delivery

    We offer an excellent worldwide delivery service. For more details, please take a look at our delivery FAQ.


    If you have changed your mind, you can return goods, at your cost, unopened within 14 days for refund or exchange, this does not affect your statutory rights.

Customer Questions

All questions answered by probiotic experts Dr Kate Stephens PhD (Food and Microbial Sciences) BSc(Hons) Medical Biology and Kerry Beeson BSc (Nut. Med.) Nutritional Therapist

Yes! In fact, it’s highly recommended.  S. boulardii does not colonise for long in the gut but it harmonises extremely well with all types of friendly bacteria, so most people take them in combination.

Our gut microbiomes are unique, so the response to Saccharomyces boulardii varies. If taking Optibac S. Boulardii supplement, each capsule contains 5 billion live cultures. Try 1-2 capsules initially (or a stronger 3-4 capsules together if desired) and increase if necessary up to a maximum of 6 capsules (30 billion live cultures) spread over the day. Within these guidelines, then take as much or as little as you need, on an occasional or ongoing basis.

Saccharomyces boulardii is one of the most highly researched strains in the world! But it’s actually a friendly yeast, not a type of bacteria. This internationally acclaimed strain has been used safely (1,2) for over 50 years around the world, but it was Optibac that first introduced a Saccharomyces boulardii supplement to the UK.

(1). McFarland L.V., (2010), ‘Systematic review and meta-analysis of Saccharomyces boulardii in adult patients’. World Journal of Gastroenterology, 16(18):2202–2222. (2). Kelesidis T, Pothoulakis C.(2012) ‘Efficacy and safety of the probiotic Saccharomyces boulardii for the prevention and therapy of gastrointestinal disorders’ Therapeutic Advances in Gastroenterology. 2012;5(2):111-125.
Read More

It’s easy to take S. boulardii live cultures – they can be taken at any time of day, with or without food! This friendly yeast is more robust than most bacteria (1), and can resist high heat, humidity, and stomach acid levels. It doesn’t need refrigeration, so you can take it with you, wherever you go!

(1). Hossain M et al., (2020) Identification and Growth Characterization of a Novel Strain of Saccharomyces boulardii Isolated From Soya Paste. Frontiers in Nutrition, 2020; 7: 27.
Read More

As a friendly yeast, Saccharomyces boulardii is hardier than most good bacteria. It survives well in very hot or humid conditions (1), doesn’t require refrigeration and can be taken with or without food. It’s the perfect ‘friend’ to take on your worldwide travels!  

(1). Hossain M et al., (2020) Identification and Growth Characterization of a Novel Strain of Saccharomyces boulardii Isolated From Soya Paste. Frontiers in Nutrition, 2020; 7: 27.
Read More

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