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Did you know that probiotics and our gut bacteria play an important role in our cholesterol levels and heart health? It may be difficult to imagine that these seemingly unrelated areas of the body, the gut and heart, are related. In fact, what happens in our gut influences cholesterol levels, inflammation, and body weight, each of which contribute to a healthy heart. Continue reading to learn about the best probiotics for cholesterol and heart health. Learn about the basics of probiotics by reading What are probiotics?
Key facts about probiotics, cholesterol and heart health covered in this article:
Before we answer this question, let’s briefly look at what cholesterol is and what it does in the body.
Cholesterol is a type of fat that is essential in the body to build cells and make hormones and bile. We get our cholesterol in part from our diet and it is also produced by our liver. Issues arise when cholesterol levels become too high, increasing the risk of heart disease and stroke. To maintain healthy cholesterol levels, a balanced diet and an active lifestyle with regular exercise is essential. It is common for individuals to also need cholesterol-lowering medication such as statins. Although effective at lowering cholesterol, statin side effects can be bothersome.
This means that natural methods and supplements to manage cholesterol levels are often sought by individuals to use alone or alongside statins, and there has been a lot of interest recently into whether probiotics are good for lowering cholesterol. In addition to other supplements associated with cholesterol management, natural practitioners and health stores are being increasingly asked if there are probiotics for high cholesterol. Certainly, probiotics are an attractive option for those who are looking for a safe and natural supplement to support healthy cholesterol levels, as are certain other plant extracts which act as ‘natural statins’.
It may come as a surprise to some people that probiotics and cholesterol metabolism are in fact related. Although probiotics are not commonly associated with cholesterol management, various clinical studies1 have indicated that supporting our gut health with specific probiotic strains may help cholesterol levels. The bacteria living in our gut influence the absorption of cholesterol from our food and the production of cholesterol in the liver.
It’s very difficult to imagine how bacteria in our gut can play a part in cholesterol management; however, it’s believed that there are several mechanisms by which probiotics may reduce cholesterol:
Some probiotic bacteria take up cholesterol from their surrounding environment and others have a sticky surface which cholesterol attaches to, preventing it from being absorbed in the gut2. Other probiotic strains prevent cholesterol from being absorbed by converting it into another compound called coprostanol3. Coprostanol cannot be absorbed in the intestines and is therefore eliminated in our stool.
Probiotic bacteria contain enzymes, which break down components of our food. Specific probiotic strains contain an enzyme called bile salt hydrolase which breaks down bile salts in the gut which are then excreted in our stools. Cholesterol is required to make more bile, so circulating cholesterol in the body is used to replace the bile salts that are lost4.
Certain probiotic strains produce the short chain fatty acid, propionic acid5 which under certain conditions can reduce the production of cholesterol by the liver6.
Clinical research published earlier this year has found that probiotics can significantly improve health in those at risk of heart disease7. An important connection exists between the gut microbiome, probiotics and heart health8. Our gut microbiome also plays a role in our cholesterol levels, weight, blood pressure levels, inflammation in the body, and oral health, each of which are important factors in heart health. Probiotics have been used in research and found to positively influence a number of factors associated with poor heart health.
As discussed previously, the bacteria in our gut influences our cholesterol levels, a known risk factor for heart disease. High cholesterol is a significant risk factor for heart attack and stroke. Raised cholesterol levels can lead to narrowing of our arteries, known as atherosclerosis. In atherosclerosis, cholesterol and other substances stick to the wall of the blood vessel forming a plaque which builds up over time, eventually blocking the artery. These blockages in our blood vessels can lead to heart attack and stroke.
Obesity, particularly visceral fat (the fat accumulated in the abdomen around our major organs), is associated with an increased risk of developing cardiovascular disease9. The gut microbiome can affect our energy metabolism and weight10,11 and is discussed further below.
High blood pressure is one of the most prominent risk factors for the development of cardiovascular disease12. Clinical studies evaluating the effects of probiotics on blood pressure levels have had encouraging results7.
Inflammation of the blood vessel wall is a fundamental component of atherosclerosis and drives its progression13. A typical Western diet, high in processed foods and lacking in fresh whole fruit and vegetables, can lower diversity of the gut microbiome and encourage the growth of bacteria associated with inflammation14. This gut microbiome imbalance, known as dysbiosis, can contribute to inflammation in the body. Taking probiotics can help to bring the gut microbiome back into balance and replenish our levels of beneficial gut bacteria. Particular probiotic strains have been shown to help reduce the production of pro-inflammatory chemical messengers in the body15, including associations with better CRP levels16. This shows that probiotics may have a positive impact on inflammatory processes in the body.
Interestingly, poor dental hygiene and gum disease are associated with heart disease17. The mouth has the highest levels of bacteria in the body, after the gut18. Poor dental health allows harmful bacteria to flourish and contributes to the development of gum inflammation and cavities19. These same oral bacteria have been found in plaques in the arteries of individuals with heart disease20. Certain probiotic strains have been found to positively contribute to the maintenance of healthy gums and teeth by reducing the growth of more harmful bacteria21. Keeping our oral microbiome healthy may play a role in our heart health. To learn more, read the article Probiotics for bad breath.
The types of bacteria residing in our gut varies depending on our weight. Obese individuals have different gut microbiome compositions in comparison to lean individuals, and with weight loss, their gut bacteria becomes more like the gut bacteria of lean individuals22.
Although the mechanisms of how the gut microbiome and probiotics can influence weight are not fully understood, it is believed to be related to the influence of the gut bacteria on energy release from food and bile metabolism.
As mentioned above, the enzyme bile salt hydrolase, in certain strains of probiotics, plays an important role in weight gain, cholesterol metabolism, and fat metabolism. High levels of bile salt hydrolase activity have been found to result in significant reduction in weight and cholesterol levels in animal studies23.
The gut microbiome also influences other factors that contribute to weight management including inflammation, fat absorption from food, and hormone levels. To learn more on this topic, healthcare professionals may like to read Could probiotics help with weight loss? on the Probiotic Professionals site.
Maintaining healthy cholesterol levels positively influences our heart health. Certain strains of the probiotic bacteria Lactobacillus have been recognised for their impact on cholesterol levels in the body.
The above strains were identified out of hundreds of screened strains to have excellent cholesterol removal ability and BSH activity in vitro5. In a gold standard trial including 60 individuals with raised cholesterol, the effects of the probiotic combination L. plantarum CECT 7527, L. plantarum CECT 7528 and L. plantarum CECT 7529 on cholesterol levels were assessed24. After three-months there were significant reductions in:
Interestingly, those with higher starting values resulted in greater reductions after probiotic supplementation.
A more recent gold standard trial found the strains to be effective alongside red yeast rice (RYR) extract25. After 12 weeks, participants displayed significant reductions in total cholesterol (12%) and LDL-C (13%), similar results to the previous trial.
The strains have also demonstrated an excellent safety profile with no tolerability issues documented in the studies above. Another trial assessed the strains alongside a variety of medications including statins, fenofibrates, antihypertensive, antidiabetic and antiplatelets26. They were shown to be safe and effective with no tolerability issues related to probiotic intake.
In another clinical trial, the probiotic strain, Lactobacillus reuteri NCIMB 30242, was also shown to help maintain healthy cholesterol levels in individuals with raised cholesterol levels25.
Other probiotics have been demonstrated influence other risk factors for cardiovascular disease such as weight and inflammation.
Certain probiotic strains including Lactobacillus rhamnosus CGMCC1.3724 have been researched for their potential in weight management and show early promising results26; however, further high quality clinical studies are required.
In a gold standard trial, the effects of the probiotics strain B. lactis HN019 was compared with a placebo in individuals with metabolic syndrome. The probiotic group demonstrated positive results in body mass index (BMI), total cholesterol levels and inflammation levels15. Healthcare professionals can read more about Bifidobacterium lactis HN019 on the Probiotics Database.
If you are interested in taking a probiotic to reduce your cholesterol but are taking medication or have additional health issues, we would always advise discussing supplementation with your GP or health practitioner. It is important not to stop any prescribed medication before talking to your doctor first.
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