25 Sep 2017
As it's PCOS awareness month, we thought it'll be great to look into this condition, and also explore how probiotics could help.
Polycystic ovary syndrome is a common endocrine condition, affecting 5-10% of women1, 2. This condition affects how the ovaries work and it’s characterised by a number of features. One of them being the formation of small underdeveloped cysts in the ovaries which can affect the menstrual cycle as some of the sacs can’t release an egg, impeding ovulation3.
Another feature of PCOS is an imbalance in sex hormones, so excess androgens are produced by the ovaries and released into the body. Although androgens are normal residents in a woman’s body as they’re converted into oestrogen, high levels are linked to PCOS and other health issues4.
PCOS is a complex condition, with no known cause or cure and it isn’t thought to be hereditary; however, it’s often linked to high levels of hormones like insulin. Often, women with this condition develop insulin resistance as their bodies become resistant to the effect of insulin, which leads to more insulin being secreted by the pancreas.
This could contribute to a number of serious health issues like type 2 diabetes, obesity, and overproduction of testosterone which can affect ovulation3.
Whilst there is no cure for PCOS, there are a number of treatments available that could help with improving individual symptoms some women struggle with. Lifestyle and dietary interventions like dietary management, exercise and losing excess weight can help with improving some symptoms.
There are also a number of natural remedies that could offer support for symptoms of PCOS. One example is A.Vogel's Molkosan® prebiotic supplement. This prebiotic product - which is rich in L+lactic acid - could help promote the growth of beneficial bacteria in the gut that are involved in the metabolism of carbohydrates.
As practitioners, I’m sure you’re wondering if and how probiotics could help with managing PCOS. Well, let's take a look at a few theories and research studies.
A theory by Tremellen & Pearce (2012) looked at dysbiosis (see Probiotics Learning Lab for glossary definitions) of the gut microbiota (DOGMA), as a possible answer to the aetiology of PCOS5. Their theory suggested that intestinal dysbiosis caused by poor diet could increase intestinal permeability which could lead to lipopolysaccharides (LPS) escaping into circulation in the body. LPS are found on the outer layer of gram negative bacteria, which can stimulate strong immune response. This immune response could lead to a cascade of events that could affect insulin levels, production of androgen and consequently the ovaries.
Guo, et al. (2016) built on this hypothesis and carried out a murine study based on the DOGMA theory6 . The study involved 32 female rats, split into 4 groups of 8. They found that Lactobacillius, Ruminococus and Clostridium were lower in the PCOS rats compared to the control. These rats also had higher Prevotella species compared to the other controls.
One PCOS group were monitored and were given faecal microbiota transplants (FMT), another PCOS group had Lactobacillus transplantation. Both groups displayed a high amount of Lactobacillus and Clostridium similar to the healthy control groups, days after the treatments. The PCOS groups that had the FMT and the transplant treatment, had an improved estrous (reproductive) cycle after the treatments. They also found that the androgen and testosterone concentration in the treated rats decreased significantly compared to the control group.
This result further demonstrate that there could be a link between the gut flora and PCOS; however, as with any animal study, more human clinical trials need to be carried out to establish if these results can be replicated.
A number of studies have found that supplementing with probiotics could have positive effects on some of the issues associated with PCOS like insulin sensitivity, inflammation and LPS production; so, supplementing with probiotics could very well help with factors associated with PCOS.
A randomised double blinded placebo study, assessed the effect of Lactobacillus acidophilus NCFM® on insulin sensitivity and systemic inflammation in male volunteers7. The study involved 43 male volunteers. They were split into two groups, each group including men diagnosed with type 2 diabetes and some with normal glucose tolerance. One group received Lactobacillus acidophilus NCFM® and the other group were given a placebo over a period of 4 weeks. Although there were no significant improvements in systemic inflammation in both groups, insulin sensitivity in the group that received the probiotic supplement improved.
This clinical trial highlights the possible role probiotics could play in supporting insulin sensitivity which is often an issue with PCOS. So, whilst this trial was carried out on men, the positive result might suggest that it could also be applicable to women with insulin sensitivity.
Another murine study also explored the effect probiotic supplementation has on reducing the production of LPS8. They found that Lactobacillus rhamnosus GR-1® significantly decreased the production of LPS-induced production of interleukin - known to stimulate immune responses like inflammation.
All in all, although the research into the effect the microbiota has on PCOS is quite promising, due to the complexity of pathogenesis of this condition, more human clinical trials will need to be carried out to further explore how probiotics can help with managing this condition.
Check out the following links for more research involving probiotics;
1. B. O. Saydam and B. o. Yildiz, "Gut-Brain Axis and Metanolism in Polycystic Ovary Syndrome," Current Pharmaceutical Design, vol. 22, no. 36, p. 5572, 2017.
2. PCOS UK, "PCOS UK," 2013. [Online]. Available: http://www.pcos-uk.org.uk/about-pcos.html. [Accessed 22 September 2017].
3. NHS, "NHS Choices," NHS, 18 03 2016. [Online]. Available: http://www.nhs.uk/conditions/polycystic-ovarian-syndrome/Pages/Introduction.aspx. [Accessed 22 September 2017].
4. M. C. N. I. F. Dr. James Simon, "Healthy Women," 2017. [Online]. Available: http://www.healthywomen.org/condition/androgen. [Accessed 22 September 2017].
5. K. Tremellen and K. Pearce, "Dysbiosis of Gut Microbiota (DOGMA) – A novel theory for the development of Polycystic Ovarian Syndrome," vol. 79, no. 1, p. 104, 2012.
6. Y. Guo, Y. Qi, X. Yang, L. Zhao, S. Wen, Y. Liu and L. Tang, "Association between Polycystic Ovary Syndrome and Gut Microbiota," Journal pone, vol. 11, no. 4, pp. 1-15, 2016.
7. A. S. Andreasen, N. Larsen, T. Pedersen-Skovsgaard, R. M. G. Berg, K. Møller, K. D. Svendsen, M. Jakobsen and B. K. Pedersen, "Effects of Lactobacillus acidophilus NCFM on insulin sensitivity and the systemic inflammatory response in human subjects," British Journal of Nutrition, vol. 104, no. 12, pp. 1831-1838, 2010.
8. S. Yang, W. Li, . J. R. Challis, . G. Reid, S. O. Kim and A. D. Bocking, "Probiotic Lactobacillus rhamnosus GR-1 supernatant prevents lipopolysaccharide-induced preterm birth and reduces inflammation in pregnant CD-1 mice," vol. 211, no. 1, p. 44, 2014.
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